Invertebrate troponin: Insights into the evolution and regulation of striated muscle contraction
نویسندگان
چکیده
منابع مشابه
Anomalous Contraction of Invertebrate Striated Muscle
The phenomenon of A band shortening or contraction has been investigated in glycerinated myofibrils of Pecten irradians, Homarus americanus, Cambarus virilis, and Limulus polyphemus through the techniques of ultraviolet microbeam inactivation and polarization microscopy. With the former method, it has been shown that these muscles, even though exhibiting the shortening effect, contract in a man...
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Ca(2+) regulation of contraction in vertebrate striated muscle is exerted primarily through effects on the thin filament, which regulate strong cross-bridge binding to actin. Structural and biochemical studies suggest that the position of tropomyosin (Tm) and troponin (Tn) on the thin filament determines the interaction of myosin with the binding sites on actin. These binding sites can be chara...
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Troponin is a heterotrimeric Ca2+-binding protein that has a well-established role in regulating striated muscle contraction. However, mounting evidence points to novel cellular functions of troponin, with profound implications in cancer, cardiomyopathy pathogenesis and skeletal muscle aging. Here, we highlight the non-canonical roles and aberrant expression patterns of troponin beyond the sarc...
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characterized by deficits in social communication and interaction, impaired language development, and stereotyped repetitive behaviors. The broader category of autism spectrum disorders (ASDs) includes individuals with subsets of these symptoms (Geschwind and Levitt, 2007). The prevalence of autism in the USA has increased since the inception of the diagnosis in the 1980s – to about 1 in every ...
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ژورنال
عنوان ژورنال: Archives of Biochemistry and Biophysics
سال: 2019
ISSN: 0003-9861
DOI: 10.1016/j.abb.2019.03.013